Alien vs. Predator: Life and Death is an ongoing four-issue limited comic book series that is being published currently by Dark Horse Comics from December 2016-March 2017. It is also being published simultaneously in the digital format via Dark Horse Digital. The story is written by Dan Abnett, illustrated by Brian Thies and colored by Rain Beredo, with cover art by David Palumbo. Sachin Teng and Carlos D'Anda also provided variant covers for the first issue.

Alien vs. Predator: Life and Death forms the Aliens vs. Predator component of Dark Horse's franchise-crossing Life and Death event in 2016/2017, and is being released in conjunction with Predator: Life and Death, Prometheus: Life and Death and Aliens: Life and Death. The four series all share an interconnected story and all were written by Abnett.

In the Aliens vs. Predator comics line, Alien vs. Predator: Life and Death is preceded by Alien vs. Predator: Fire and Stone.