Using duplicates of himself in order to constantly learn new knowledge and abilities, Jamie Madrox formed a detective agency in District X with long-time friends Guido and Rahne. The agency was originally named XXX Investigators and their first case was investigating the murder of one of Jamie's duplicates. After the long and involved case, it was actually Guido who recommended changing the name of the agency to "X-Factor Investigations" as an homage to the superhero team to which they all once belonged. However, this new incarnation of X-Factor has no relation with the U.S. government, as the previous teams.