Superhuman Strength: The Living Brain was able to analyze the strength of Spider-Man's webbing, deciding how much pressure to apply, and then plowed right through it.

Superhuman Durability: The Living Brain was able to withstand multiple energy attacks from theParker Industries S.W.A.T.-Bots. 

Programmable Intelligence: The Living Brain has a hard drive stored in its body to allow it to store unlimited amount of data and has the potential to contain more knowledge than any other brain on earth, human or mechanical. It was able to think so fast it was able to second-guess Spider-Man's actions.

Self-Repairing System: The Living Brain was able to used the nanites stored in himself, to self-repair his body when he was damaged.