Cable is an Alpha-mutant, a vastly powerfultelepath and an Omega Level Telekinetic. Possibly an Omega Level Telepath stating before his powers burned out that he was the worlds most powerful Telepath.

As an infant Cable was infected with the Techno-Organic Virus and, for the majority of his life, had to consciously keep the virus in check so that it did not consume more of his organic flesh.

A future Rachel Summers spoke of him in a vision that at his peak he'd be a psionic of The Highest Order. In the rare instances when he was not preoccupied with staving off his T.O. infection Nathan shown powerful abilities.

When Cable was de-aged in the House of M event, he had regained his powers along with new powers and abilities but as he re-aged he began losing the majority of his powers shortly after purging Deadpool of certain malignancies.

Recently, his body was completely healed from the virus by Hope Summers, he has demonstrated Telepathy since this has happened, it is unknown to what extent or even if any others re-emerge. His telepathy was made to evolve byBlaquesmith and Stryfe (Hope Summers), using a Deathlok to grant him Precognition. That process was slowly killing him, as this new evolution caused a tumor to form in his mind that was steadily eating away at his psyche and physicality all to allow him far sight of potential disasters before they came to pass. Nowadays it is only powerful enough to permit him a couple minutes to a few seconds insight due to his powers weakening again.

Thanks to his endevours to stop a tragedy and the eventual curing of a mental time cancer he contracted with Wade's help, Cable's psychic powers were once again restored.